Favourable acceptance of mini-tablets in young babies
A study demonstrated that mini-tablets were more acceptable than syrup in children aged 6 months to 6 years. Given these positive findings, a study was conducted to assess the acceptability and swallowability of uncoated mini-tablets compared with syrup in 151 young babies aged 2 to 28 days old. Even in young babies, no difference was observed between the acceptability and swallowability of mini-tablets and syrup. Acceptability was 100% for both formulations. Swallowability was also high: 82.2% for mini-tablets and 72.2% for syrup. No babies inhaled the formulations or coughed during swallowing.
Klingmann et al. stated that:
- ‘Our results show that 1 mini-tablet may be safely administered even in neonates and that they actually swallow mini-tablets better than syrup.’
- ‘Our data close the age gap in current data referring to neonates and open the perspective for introducing such a small-sized solid drug formulations as a single formulation for all children including the very young, thus, further shifting the paradigm from liquid towards such small-sized solid drug formulations for children, as the World Health Organization proposes.’
Klingmann , V., et al. (2015). Acceptability of Uncoated Mini-Tablets in Neonates—A Randomized Controlled Trial. The Journal of Pediatrics. Vol 167(4): 893-96.e2. Available from: DOI: 10.1016/j.jpeds.2015.07.010.

INT-NON-24-0004 Date Updated: January 2024